발표논문

제목 [과민성 장 증후군] 한방과립제와 유산균 복합제제 병행 투여가 설사형 과민성 장증후군에 미치는 효능 연구
한방과립제와 유산균 복합제제 병행 투여가 설사형 과민성 장증후군에 미치는 효능 연구
Effect of Korean Herbal Medicine Combined with a Probiotic Mixture on Diarrhea-Dominant Irritable Bowel Syndrome: A Double-Blind, Randomized, Placebo-Controlled Trial
저자 고석재, 한가진, 김슬기, 서재구, 정원석, 류봉하, 김진성, 여인권, 이범준, 이진무, 박재우
저널명 Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 824605, 10 pages
게재일 2013.11.15.
논문소개
-초록정리
Introduction. : Although combination therapy with herbal medicine and probiotics is gaining popularity for controlling diarrhea-dominant irritable bowel syndrome (D-IBS) symptoms, few studies have investigated its clinical effects.

Materials and Methods. : Fifty-three patients with D-IBS were randomly allocated into 1 of the following 4 groups: herbal medicine (Gwakhyangjeonggisan; GJS) plus probiotics (Duolac7S; DUO), GJS plus placebo DUO, placebo GJS plus DUO, and placebo GJS plus placebo DUO. The study period consisted of a 2-week run-in, 8 weeks of administration, and 2 weeks of follow-up. The primary outcomes were weekly adequate relief (AR) of overall IBS symptoms and the proportion of responders (PR) during the administration period. The secondary outcomes included individual IBS symptoms, stool assessment, and quality of life. Changes of intestinal microbiota and intestinal permeability were also analyzed.

Results and Discussion. : Weekly AR was not different among the 4 groups throughout the treatment period. However, the 3 treatment groups exhibited significant improvements in PR compared to the findings in the placebo group. In the intestinal microbiota assessment, herbal medicine and probiotics synergistically increased beneficial bacteria counts.

Conclusion. : Combination therapy with herbal medicine and probiotics appears to relieve overall IBS symptoms by synergistically increasing beneficial intestinal microbe counts.
페이지 URL http://www.hindawi.com/journals/ecam/2013/824605/
연구가 가지는 의의 본 연구는 과민성 장 증후군(IBS)의 대표적 처방인 곽향정기산과 유산균제제의 과민성 장 증후군에 대한 효과를 검증한 임상논문으로서 두 시험약의 시너지 효과의 가능성을 보았다는데에 의의가 있다. 또한 IBS의 효과를 검증하는 데에 객관적 지표인 장내 유산균과 장내 투과도를 관찰하여 그 객관성을 높였으며 성상과 맛, 색깔을 표현하기 어려운 한약 제제에 대한 placebo를 썼다는데에 한의학 연구에 있어서 진일보한 면모를 보였다고 할 수 있다.

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