발표논문

제목 [한약 안전성] 한약이 와파린 복용 환자의 INR에 영향을 미치는지에 대한 후향적 연구
한약이 와파린 복용 환자의 INR에 영향을 미치는지에 대한 후향적 연구
Do Herbal Formulas Influence the International Normalized Ratio of Patients Taking Warfarin? A Retrospective Study
저자 강동경희대병원 의료진 : 고창남(교신저자), 여서원(1저자), 조승연(공동), 박성욱(공동), 박정미(공동), 고창남(공동)
타기관 의료진 : 정우상(공동), 문상관(공동)
저널명 Evidence-Based Complementary and Alternative Medicine 2015;213927
게재일 2015.05.01.
논문소개
-초록정리
Warfarin is a common anticoagulant agent for cardiovascular diseases, and it is known to interact with several foods and drugs.
Several studies report an interaction between warfarin and herbal medicines; however, the influence of herbal medicines on the international normalized ratio (INR) is still controversial. We investigated the influence of herbal formulas on INR of patients taking warfarin. We searched electronic medical records of inpatients for INR results. Then, we compared the changes in INR and any adverse events between the group taking herbal formulas and warfarin (herbal group) and another group taking warfarin only (nonherbal group). Eighty-six patients were included; 45 patients were assigned to the herbal group and 41 patients to the nonherbal group. The herbal group had taken the same dose of warfarin for a longer period. The nonherbal group had a slightly higher mean INR value than the herbal group. The ratio of INR less than 2 and greater than 3, the ratio of INR that increased or decreased by one or more compared to the initial INR, and the ratio of adverse events were not significantly different between the two groups. It is suggested that use of herbal formulas may not influence INR value.
페이지 URL http://www.hindawi.com/journals/ecam/2015/213927/abs/

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