발표논문

제목 전이성 신장암의 치료에 Rhus verniciflua stokes 추출물이 가능성 있는 대안이 될 수 있음
전이성 신장암의 치료에 Rhus verniciflua stokes 추출물이 가능성 있는 대안이 될 수 있음
Rhus verniciflua Stokes extract as a potential option for treatment of metastatic renal cell carcinoma: report of two cases
저자 Lee SK, Jung HS, Eo WK, Lee SY, Kim SH, Shim BS.
저널명 Annals of Oncology
게재일 2010.06
논문소개 Rhus verniciflua Stokes (RVS) has been used in Traditional Korean Medicine as a herbal therapy for the treatment of abdominal masses since the 15th century AD and showed anticancer efficacies in several in vitro studies. The medical use of RVS has been limited because of its toxic allergen, urushiol, which causes dermatitis. However, we have developed aRVS extract, which has been depleted of urushiol. In vivo studies of aRVS have reported that aRVS suppressed tumor growth in animal studies. The aRVS also inhibited the proliferation and migration activity of human umbilical vein endothelial cells.

We report two patients diagnosed with advanced renal cell carcinoma with multiple metastases, who were successfully treated with the allergen-removed Rhus verniciflua Stokes (aRVS) extract. In these cases, of RCC patients with clinically or pathologically diagnosed multiple metastases, demonstrate complete responses to the monotherapy of aRVS. Furthermore, the responses have lasted over 31 months and 29 months after the initiation of aRVS therapy. These cases indicate that aRVS is a promising alternative for the management of unresectable RCC with multiple metastases. However, further biological research on aRVS and prospective clinical trials are required to confirm the safety and the efficacy of aRVS.
페이지 URL http://www.ncbi.nlm.nih.gov/pubmed/?term=20363807

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