발표논문

제목 [실험연구] Paeonol이 염증매개성 신경독성와 미세아교세포 활성을 약화시킨다
Paeonol이 염증매개성 신경독성와 미세아교세포 활성을 약화시킨다
Paeonol attenuates inflammation-mediated neurotoxicity and microglial activation
저자 강동경희대병원 의료진 : 박성욱(공동), 배형섭(공동), 고창남(공동)
타기관 의료진: 황은주(교신저자), 남경년(1저자), 우병철(공동), 문상관(공동), 박주영(공동), 황재웅(공동)
저널명 Neural Regeneration Research 2013;8(18):1637–1643
게재일 2013.06.25.
논문소개
-초록정리
Chronic activation of microglial cells endangers neuronal survival through the release of various proinflammatory and neurotoxic factors. The root of Paeonia lactiflora Pall has been considered useful for the treatment of various disorders in traditional oriental medicine. Paeonol, found in the root of Paeonia lactiflora Pall, has a wide range of pharmacological functions, including anti-oxidative, anti-inflammatory and neuroprotective activities. The objective of this study was to examine the efficacy of paeonol in the repression of inflammation-induced neurotoxicity and microglial cell activation. Organotypic hippocampal slice cultures and primary microglial cells from rat brain were stimulated with bacterial lipopolysaccharide. Paeonol pretreatment was performed for 30 minutes prior to lipopolysaccharide addition. Cell viability and nitrite (the production of nitric oxide), tumor necrosis factor-alpha and interleukin-1beta products were measured after lipopolysaccharide treatment. In organotypic hippocampal slice cultures, paeonol blocked lipopolysaccharide-related hippocampal cell death and inhibited the release of nitrite and interleukin-1beta. Paeonol was effective in inhibiting nitric oxide release from primary microglial cells. It also reduced the lipopolysaccharide-stimulated release of tumor necrosis factor-alpha and interleukin-1β from microglial cells. Paeonol possesses neuroprotective activity in a model of inflammation-induced neurotoxicity and reduces the release of neurotoxic and proinflammatory factors in activated microglial cells.
페이지 URL http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145915/

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