발표논문

제목 [실험연구] Butylidenephthalide의 염증 매개성 신경독성에 대한 예방과 뇌신경교세포의 활성에 대한 연구
Butylidenephthalide의 염증 매개성 신경독성에 대한 예방과 뇌신경교세포의 활성에 대한 연구
Prevention of inflammation-mediated neurotoxicity by butylidenephthalide and its role in microglial activation
저자 강동경희대병원 의료진 : 박정미(공동), 조승연(공동)
타기관 의료진 : 황은주(교신저자), 남경년(1저자), 김규필(공동), 조기호(공동), 정우상(공동), 박수경(공동), 박태훈(공동), 김영석(공동)
저널명 Cell Biochemistry and Function 2013;31(8):707-712
게재일 2013.02.11.
논문소개
-초록정리
Microglial cells are the prime effectors in immune and inflammatory responses of the central nervous system (CNS). During pathological conditions, the activation of these cells helps restore CNS homeostasis. However, chronic microglial activation endangers neuronal survival through the release of various proinflammatory molecules and neurotoxins. Thus, negative regulators of microglial activation have been considered as potential therapeutic candidates to target neurodegeneration, such as that in Alzheimer's and Parkinson's diseases. The rhizome of Ligusticum chuanxiong Hort. (Ligusticum wallichii Franch) has been widely used for the treatment of vascular diseases in traditional oriental medicine. Butylidenephthalide (BP), a major bioactive component from L. chuanxiong, has been reported to have a variety of pharmacological activities, including vasorelaxant, anti-anginal, anti-platelet and anti-cancer effects. The aim of this study was to examine whether BP represses microglial activation. In rat brain microglia, BP significantly inhibited the lipopolysaccharide (LPS)-induced production of nitric oxide (NO), tumour necrosis factor-α and interleukin-1β. In organotypic hippocampal slice cultures, BP clearly blocked the effect of LPS on hippocampal cell death and inhibited LPS-induced NO production in culture medium. These results newly suggest that BP provide neuroprotection by reducing the release of various proinflammatory molecules from activated microglia.
페이지 URL http://onlinelibrary.wiley.com/doi/10.1002/cbf.2959/ abstract;jsessionid=F077C346F95C4F7C6E7DC240E371A765.f01t01

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