발표논문

제목 [파킨슨병] 천마가 파킨슨 쥐의 FosB and ERK 활동을 정상화하여 L-DOPA로 인한 이상운동증을 경감시킨다.
천마가 파킨슨 쥐의 FosB and ERK 활동을 정상화하여 L-DOPA로 인한 이상운동증을 경감시킨다.
Gastrodia elata Blume alleviates L-DOPA-induced dyskinesia by normalizing FosB and ERK activation in a 6-OHDA-lesioned Parkinson’s disease mouse model
저자 강동경희대병원 의료진 : 박성욱(교신저자)
타기관 의료진 : 박히준(교신저자), 두아름(1저자), 김승남(공동), 함대현(공동), 유혜현(공동), 박지연(공동), 이혜정(공동), 전송희(공동), 김종필(공동)
저널명 BMC Complementary and Alternative Medicine 2014;14:107
게재일 2014.03.20.
논문소개
-초록정리
Background : Gastrodia elata Blume (GEB), commonly used medicinal herb, has been reported as a promising candidate for neurodegenerative diseases such as Parkinson’s disease. The dopamine precursor, L-3,4-dihydroxyphenylalanine (L-DOPA), is the gold-standard drug for Parkinson’s disease, but long-term treatment results in the L-dopa-induced dyskinesia (LID). This study was undertaken to examine the beneficial effects of GEB on L-DOPA induced dyskinesia in 6-hydroxydopamine (6-OHDA)-induced experimental Parkinsonism.

Methods : We tested the effects of GEB on LID in 6-hydroxydopamine hydrochloride-hemiparkinsonian mice. To analyze the dyskinetic anomalies, we measured abnormal involuntary movement (AIM). Immunohistological analyses of pERK and FosB expressions in the striatum are performed to explore the mechanism of GEB on LID.

Results : The finding of this study demonstrated that GEB (200, 400 and 800 mg/kg) alleviated L-dopa induced AIMs in a dose-dependent manner. In each integrative AIM subtype analysis, we also found that the GEB (400 and 800 mg/kg) treatment decreased L-DOPA-induced axial, limb, orolingual, and locomotive AIMs compared to the LID group. In addition, GEB normalized the abnormal LID-induced increase of pERK1/2 and FosB, the immediate early genes of LID in the striatum.

Conclusions : In conclusion, our results provide a novel insight into the pharmacological actions of GEB that could have a benefit for PD patients through the reduction of LID.
페이지 URL http://www.biomedcentral.com/1472-6882/14/107

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