발표논문

제목 [대뇌 죽상경화증] 두개내 대뇌혈관의 무증상성 죽상동맥경화증의 위험도에 대한 성별 차이 분석
두개내 대뇌혈관의 무증상성 죽상동맥경화증의 위험도에 대한 성별 차이 분석
Gender differences in risk factors for intracranial cerebral atherosclerosis among asymptomatic subjects
저자 강동경희대병원 의료진 : 박성욱(공동), 박정미(공동)
타기관 의료진 : 문상관(교신저자), 김영석(1저자), 홍진우(공동), 정우상(공동), 조성일(공동), 부영민(공동), 문상관(공동)
저널명 Gender Medicine 2011;8(1):14-22.
게재일 2011.04.15.
논문소개
-초록정리
Background : Gender is known to be one of the factors linked to differences in cardiovascular morbidity and mortality. However, little information is available regarding gender differences in the risk factors for intracranial cerebral atherosclerosis (ICAS).

Objectives : This study investigated the risk factors for ICAS separately by gender in an asymptomatic population.

Objective : This study investigated the risk factors for ICAS separately by gender in an asymptomatic population.

Methods : We collected data from a consecutive series of 935 subjects who had no history of stroke and who had undergone transcranial Doppler ultrasonography (TCD). For each subject, their medical history was documented and tests for biochemical markers were performed. Multiple logistic regression analyses were separately conducted to assess the risk factors associated with ICAS by gender.

Results : The risk factors for asymptomatic ICAS were determined for every 10-year increase in age (odds ratio [OR] = 1.74, 95% confidence interval [CI] = 1.23-2.46), diabetes mellitus (DM) (OR = 3.45, 95% CI = 1.49-7.95), smoking (OR = 2.09, 95% CI = 1.01-4.32), and hypercholesterolemia (OR = 3.31, 95% CI = 1.15-9.50) for male subjects; risk factors female subjects included hypertension (OR = 2.10, 95% CI = 1.40-3.15) and DM (OR = 2.45, 95% CI = 1.11-5.44). An additional stratified analysis indicated that there was no significant risk factor for male subjects aged <50 years, whereas hypertension (OR = 2.90, 95% CI = 1.57-5.37) was the significant risk factor for female subjects aged <50 years. For male subjects aged ≥50 years, DM (OR = 6.00, 95% CI = 1.87-19.20), hypercholesterolemia (OR = 4.72, 95% CI = 1.05-21.19), and every 10-year increase in age (OR = 4.33, 95% CI = 2.02-9.28) were significant risk factors for asymptomatic ICAS, whereas DM (OR = 2.93, 95% CI = 1.14-7.48) was significant for female subjects aged ≥50 years.

Conclusions : The findings suggest that the risk factors for asymptomatic ICAS differ between sexes, indicating a possible role of sex hormones in the development of ICAS.
페이지 URL http://www.sciencedirect.com/science/article/pii/S1550857911000027

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