발표논문

제목 [뇌혈관] 정상인에서 혈부축어탕의 적혈구 변형능과 뇌혈관 CO2 반응도에 대한 연구
정상인에서 혈부축어탕의 적혈구 변형능과 뇌혈관 CO2 반응도에 대한 연구
Effects of Hyul-Bu-Chuke-Tang on Erythrocyte Deformability and Cerebrovascular CO(2) Reactivity in Normal Subjects.
저자 강동경희대병원 의료진 : 박정미(공동), 박성욱(공동), 조승연(공동)
타기관 의료진 : 문상관(교신저자), 정우상(1저자), 박주영(공동), 변형식(공동), 김영지(공동)
저널명 Evid Based Complement Alternat Med. 2012;725241
게재일 2012.05.28.
논문소개
-초록정리
Aim. Hyul-bu-chuke-tang (HCEt) is a well-known traditional herbal medicine that is used for the treatment of ischemic cerebrovascular disorders. We investigated the acute effects of HCEt on erythrocyte deformability and cerebrovascular CO(2) reactivity (CVR) in healthy male subjects. Materials and Methods. We examined erythrocyte deformability in an HCEt group (n = 14) and a control group (n = 10). CVR was measured using hyperventilation-induced CO(2) reactivity of the middle cerebral artery and transcranial Doppler (TCD) in the HCEt group (n = 11). A historical control group (n = 10) of CVR measurements was also created from our previous study. All measurements were performed prior to and 1, 2, and 3 hours after HCEt administration. Results. HCEt significantly improved erythrocyte deformability 1 hour after administration compared to the control group (2.9 ± 1.1% versus -0.6 ± 1.0%, P = 0.034). HCEt significantly improved the CVR 2 hours after administration compared to the historical control group (9.1 ± 4.0% versus -8.1 ± 4.1%, P = 0.007). The mean blood pressure and pulse rate did not vary from baseline values in either group. Conclusions. We demonstrated that HCEt improved erythrocyte deformability and CVR. Our findings suggest that an improvement in erythrocyte deformability contributes to HCEt's effect on cerebral microcirculation.
페이지 URL http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368491/

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