발표논문

제목 [청혈단] 소혈관 중풍환자에서 청혈단의 중풍 재발 억제 효과에 대한 예비 연구
소혈관 중풍환자에서 청혈단의 중풍 재발 억제 효과에 대한 예비 연구
A preliminary study on the inhibitory effect of Chunghyul-dan on stroke recurrence in patients with small vessel disease
저자 강동경희대병원 의료진 : 박성욱(공동), 박정미(공동), 고창남(공동), 배형섭(공동)
타기관 의료진 : 조기호(1저자), 노기환(공동), 정우상(공동), 문상관(공동), 김영석(공동)
저널명 Neurological Research 2008;30(6):655-658
게재일 2008.07.07.
논문소개
-초록정리
Objective : Chunghyul-dan is a combinatorial herbal medicine, and previous works reported that it had therapeutic effects for microangiopathy, which is a major part in the progression of small vessel disease, as having anti-hypertensive, anti-hyperlipidemic, anti-apoptotic, anti-oxidative and anti-inflammatory activities. Therefore, we examined the inhibitory effect of Chunghyul-dan on stroke recurrence in patients with small vessel disease.

Methods : We prescribed Chunghyul-dan 600 mg a day to the patients with small vessel disease, and monitored stroke recurrence, drug compliances and adverse effect for 2 years. And then we performed follow-up brain MRI to find new vascular lesion after 2 years of Chunghyul-dan medication. As for the control, we recruited the subjects who had been managed with antiplatelet agents from a western medical hospital, and compared the rate of stroke recurrence.

Results : There were 148 subjects who had been treated with Chunghyul-dan for 2 years, and new vascular events were found in three subjects. On the other hand, 208 subjects were managed with anti-platelet agents for 2 years in a Western medical hospital, and 17 of them had stroke recurrence. Therefore, 2 years of Chunghyul-dan medication reduced the odds ratio of stroke recurrence by 77% compared to the anti-platelet agents managed control. The inhibition rate increased to 79%, when adjusted for other relevant risk factors for stroke occurrence. During the study, no adverse effect was detected.

Conclusion : We suggest that Chunghyul-dan could be useful for inhibition of stroke recurrence by preventing the progression of microangiopathy. Further study with a randomized controlled trial is needed to confirm this suggestion.
페이지 URL http://www.maneyonline.com/doi/abs/10.1179/174313208X305382?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed

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