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제목 [항염증효과] 쥐 뇌의 Microglia 세포에서 Crocin과 Crocetin의 항염증효과 연구
쥐 뇌의 Microglia 세포에서 Crocin과 Crocetin의 항염증효과 연구
Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells
저자 강동경희대병원 의료진 : 박성욱(공동)
타기관 의료진 : 황은주(교신저자), 남경년(1저자), 박영민(공동), 정훈지(공동), 이정연(공동), 민병덕(공동,) 정우상(공동), 조기호(공동), 박지호(공동), 강인석(공동), 홍정우(공동)
저널명 European Journal of Pharmacology 2010;648(1-3):110-116
게재일 2010.12.
논문소개
-초록정리
Microglial cells play critical roles in the immune and inflammatory responses of the central nervous system (CNS). Under pathological conditions, the activation of microglia helps in restoring CNS homeostasis. However, chronic microglial activation endangers neuronal survival through the release of various proinflammatory and neurotoxic factors. Thus, negative regulators of microglial activation have been considered as potential therapeutic candidates to target neurodegeneration, such as that observed in Alzheimer's and Parkinson's diseases. Crocin and crocetin, found in the fruits of gardenia and in the stigmas of saffron, have been considered for the treatment of various disorders in traditional oriental medicine. Crocin and crocetin have been reported to have diverse pharmacological functions, such as anti-hyperlipidemic, anti-atherosclerotic, and anti-cancer effects. Specifically, the neuroprotective potential of crocetin derivatives has previously been demonstrated. The specific aim of this study was to examine whether crocin or crocetin represses microglial activation. Crocin and crocetin were shown to be effective in the inhibition of LPS-induced nitric oxide (NO) release from cultured rat brain microglial cells. These compounds reduced the LPS-stimulated productions of tumor necrosis factor-α, interleukin-1β, and intracellular reactive oxygen species. The compounds also effectively reduced LPS-elicited NF-κB activation. In addition, crocin reduced NO release from microglia stimulated with interferon-γ and amyloid-β. In organotypic hippocampal slice cultures, both crocin and crocetin blocked the effect of LPS on hippocampal cell death. These results suggest that crocin and crocetin provide neuroprotection by reducing the production of various neurotoxic molecules from activated microglia.
페이지 URL http://www.sciencedirect.com/science/article/pii/S0014299910008836

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