발표논문

제목 [실험연구] 쥐의 뇌 미세아교세포에서 genipin의 염증반응 억제에 관한 연구
쥐의 뇌 미세아교세포에서 genipin의 염증반응 억제에 관한 연구
Genipin inhibits the inflammatory response of rat brain microglial cells
저자 강동경희대병원 의료진 : 박정미(공동)
타기관 의료진 : 황은주(교신저자), 남경년(1저자), 최요섭(공동), 정훈지(공동), 박건혁(공동), 문상관(공동), 조기호(공동), 강철훈(공동), 강인석(공동), 오명숙(공동)
저널명 International Immunopharmacology 2010;10(4):493–499
게재일 2010.04.
논문소개
-초록정리
Microglia are the prime effectors in immune and inflammatory responses of the central nervous system (CNS). Under pathological conditions, the activation of these cells helps restore CNS homeostasis. However, chronic microglial activation endangers neuronal survival through the release of various proinflammatory and neurotoxic factors. Thus, negative regulators of microglial activation have been considered as potential therapeutic candidates to target neurodegeneration, such as that in Alzheimer's and Parkinson's diseases. Genipin, the aglycon of geniposide found in gardenia fruit has long been considered for treatment of various disorders in traditional oriental medicine. Genipin has recently been reported to have diverse pharmacological functions, such as antimicrobial, antitumor, and anti-inflammatory effects. The specific aim of this study was to examine whether genipin represses brain microglial activation. Genipin was effective at inhibiting LPS-induced nitric oxide (NO) release from cultured rat brain microglial cells. Genipin reduced the LPS-stimulated production of tumor necrosis factor-α, interleukin-1β, prostaglandin E2, intracellular reactive oxygen species, and NF-κB activation. In addition, genipin reduced NO release from microglia stimulated with interferon-γ and amyloid-β. Both pretreatment and post-treatment of genipin to LPS-stimulated microglia were effective at decreasing NO release. Furthermore, genipin effectively inhibited microglial activation in a mouse model of brain inflammation. These results suggest that genipin provide neuroprotection by reducing the production of various neurotoxic molecules from activated microglia.
페이지 URL http://www.sciencedirect.com/science/article/pii/S156757691000038X

목록