발표논문

제목 [청혈단] 청혈단은 상완발목 맥파전달속도가 증가된 환자의 동맥경화를 개선시킨다.
청혈단은 상완발목 맥파전달속도가 증가된 환자의 동맥경화를 개선시킨다.
Chunghyul-Dan (Qingxie-Dan) improves arterial stiffness in patients with increased baPWV
저자 강동경희대병원 의료진 : 박성욱(1저자), 고창남(공동), 배형섭(공동)
타기관 의료진 : 정우상(교신저자), 문상관(공동), 조기호(공동), 김영석(공동)
저널명 The American Journal of Chinese Medicine 2006;34(4):553-563
게재일 2006.01.30.
논문소개
-초록정리
Arterial stiffness is an important, independent determinant of cardiovascular risk. Pulse wave velocity (PWV) has been used as a valuable index of arterial stiffness and as a surrogate marker for atherosclerosis. Chunghyul-dan (CHD) has anti-hyperlipidemic activity, anti-inflammatory activity and anti-atherogenic effects. To determine its clinical effect on increased arterial stiffness, we examined whether CHD improves arterial stiffness in patients with increased brachial-ankle PWV (baPWV). Thirty-five subjects with increased baPWV (> 1400 cm/sec) were recruited and randomized to a treatment group (20 subjects) or a control group (15 subjects). The treatment group was administered CHD at a dose of 600 mg three times a day for 8 weeks, and the control group received no medication (observation only). baPWV was assessed using a pulse pressure analyzer at baseline and after 8 weeks. Blood pressure and serum lipid profile were monitored in the treatment group. Our results indicate that baPWV was lowered significantly in the treatment group after 8 weeks of medication (p < 0.05), but not in the control group. Moreover, there were no significant changes in blood pressure and serum lipids profile except triglyceride level suggesting that the effect is largely independent of CHD's lipid-lowering effect or a blood pressure change. In conclusion, CHD appears to improve arterial stiffness in patients with increased PWV.
페이지 URL http://www.worldscientific.com/doi/abs/10.1142/S0192415X06004090?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed

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